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golden empire jili slot NEW YORK , Dec. 4, 2024 /PRNewswire/ -- Report with market evolution powered by AI - The global precision medicine market size is estimated to grow by USD 66.2 billion from 2024-2028, according to Technavio. The market is estimated to grow at a CAGR of 12.34% during the forecast period. Growing prevalence of chronic diseases is driving market growth, with a trend towards growing use of artificial intelligence (AI) and machine learning (ML) in precision medicine. However, data privacy and security issues associated with precision medicine poses a challenge. Key market players include AbbVie Inc., Amgen Inc., AstraZeneca Plc, Biocrates Life Sciences AG, Bristol Myers Squibb Co., Catalent Inc., Eli Lilly and Co., F. Hoffmann La Roche Ltd., Gilead Sciences Inc., IQVIA Holdings Inc., Johnson and Johnson Services Inc., Lonza Group Ltd., Merck and Co. Inc., Novartis AG, Parexel International Corp., Pfizer Inc., QIAGEN NV, Sanofi SA, Takeda Pharmaceutical Co. Ltd., and Thermo Fisher Scientific Inc.. AI-Powered Market Evolution Insights. Our comprehensive market report ready with the latest trends, growth opportunities, and strategic analysis- View Free Sample Report PDF Key Market Trends Fueling Growth The Precision Medicine Market is experiencing significant growth due to the increasing focus on personalized treatment for various diseases. This approach takes into account environmental, genetic, and behavioral variability to understand illness susceptibility and disease progression. Precision medicine is revolutionizing the way we diagnose and treat conditions such as chromosomal abnormalities in fetuses, cancer, chronic diseases, CNS Disorders including Alzheimer's disease, Epilepsy, and Multiple Sclerosis. Companies like Cleveland Clinic are leading the way with companion diagnostics and genetic testing, using genes and proteins to develop personalized treatment drugs. Technologies like single nucleotide polymorphism detection, microarray/biochips, and genome sequencing are key tools in this field. The biopharmaceutical arena is embracing precision medicine, with Orchard Therapeutics being a notable player. However, reimbursement policies, calculation methodology, and regulatory challenges remain. The market presents numerous opportunities for targeted gene therapy, pharmacogenomics, and personalized therapeutics. Despite these challenges, positive results are driving commercialization. Gene sequencing and genetics and genomics research are paving the way for precision medicine access and wider adoption, even in developing regions. Rare genetic disorders and other rare diseases are also benefiting from this therapeutic approach. The future of healthcare lies in the development and commercialization of precision medicine treatments. Precision medicine is experiencing significant advancements with the integration of Artificial Intelligence (AI) and Machine Learning (ML) technologies. These technologies facilitate the analysis of extensive patient data, leading to more targeted and personalized treatments. In the realm of diagnosis, AI and ML algorithms enhance clinicians' capabilities, enabling risk prediction and therapy planning. Drug discovery also benefits from these technologies, as AI and ML can identify potential drug targets and predict new drugs' efficacy, expediting the drug development process. Insights on how AI is driving innovation, efficiency, and market growth- Request Sample! The Precision Medicine Market is experiencing significant growth due to the increasing understanding of the role of genetic, environmental, and behavioral variability in illness susceptibility and disease progression. This market encompasses prescription medicines for chromosomal abnormalities like Down Syndrome, cancer, chronic diseases such as Alzheimer's disease, epilepsy, and multiple sclerosis. Companies like Cleveland Clinic and Orchard Therapeutics are leading the way with companion diagnostics, genetic testing, and personalized therapeutics. However, challenges include environmental variability, genetic variability, and behavioral variability, as well as reimbursement policies, calculation methodology, and regulatory hurdles. Market opportunities lie in targeted gene therapy, genome sequencing, and personalized treatment choices based on molecular profiles and clinical characteristics. Biopharmaceutical players in the oncology application are investing in drug discovery technology, pharmacogenomics, pharmacokinetics, and pharmacodynamics to develop and commercialize precision medicine therapeutics. Despite these challenges, the potential for positive results and wider adoption, especially for rare genetic disorders and other rare diseases, makes this a promising area for the biopharmaceutical arena. The precision medicine market faces a significant challenge in ensuring data privacy and security. With the collection and analysis of large patient datasets, including genetic and molecular information, medical history, and lifestyle factors, comes the responsibility to protect this sensitive data from unauthorized access and misuse. Precision medicine data is highly valuable and a potential target for cyberattacks and data breaches. To mitigate this risk, researchers and healthcare providers must implement security measures. These measures include encryption, firewalls, and other security technologies to safeguard data during storage and transmission. Ensuring data privacy and security is crucial to maintain patient trust and confidence in the precision medicine industry. Insights into how AI is reshaping industries and driving growth- Download a Sample Report Segment Overview This precision medicine market report extensively covers market segmentation by 1.1 Oncology 1.2 CNS 1.3 Respiratory 1.4 Immunology 1.5 Others 2.1 Bioinformatics 2.2 Gene sequencing 2.3 Drug discovery 2.4 Precision molecular diagnostic 2.5 Big data analytics 3.1 North America 3.2 Europe 3.3 Asia 3.4 Rest of World (ROW) 1.1 Oncology- Precision medicine is revolutionizing the field of oncology by enabling doctors to create customized treatment plans based on a patient's unique genetic and biomarker data. In oncology, this approach allows for the identification of high-risk individuals, early cancer detection, precise cancer type identification, effective treatment selection, and treatment efficacy analysis. Two notable examples of precision medicine in oncology are molecularly targeted therapies and immunotherapy. Molecularly targeted therapies are drugs designed to inhibit specific molecular pathways driving cancer growth, minimizing damage to healthy cells. Immunotherapy harnesses the patient's immune system to fight cancer by targeting molecular markers on cancer cells, leading to better treatment outcomes and fewer side effects. Precision medicine also plays a crucial role in identifying individuals at higher risk for certain cancers, such as breast and ovarian cancer, by analyzing genetic data for mutations like BRCA1 and BRCA2. The growing adoption of precision medicine in oncology will significantly contribute to the expansion of the global precision medicine market in the oncology segment during the forecast period. Download complimentary Sample Report to gain insights into AI's impact on market dynamics, emerging trends, and future opportunities- including forecast (2024-2028) and historic data (2018 - 2022) Research Analysis Precision medicine is a revolutionary approach to healthcare that takes into account the unique genetic, behavioral, and environmental variabilities of each individual to provide personalized treatment. This approach is particularly important in the context of illness susceptibility, as it can help identify those at higher risk for chronic diseases such as cancer, CNS disorders including Alzheimer's disease, epilepsy, and multiple sclerosis. The diagnosis and progression of these conditions can be influenced by various genetic and chromosomal abnormalities. High cost is a significant challenge in the precision medicine market, with the need for expensive genetic testing, prescription medicines, and companion diagnostics. Single nucleotide polymorphisms and genome sequencing are essential tools in precision medicine, enabling the identification of positive results for personalized therapeutics. Targeted gene therapy and personalized treatment drugs are key components of precision medicine, with reimbursement policies playing a crucial role in their commercialization. Prevalence of cancer and other chronic diseases continues to rise, making the need for precision medicine more urgent than ever. Despite these challenges, the potential benefits of this approach are significant, offering the promise of more effective and personalized healthcare solutions. Market Research Overview Precision Medicine Market refers to the emerging field of healthcare that utilizes genetic, environmental, and behavioral data to develop personalized treatment plans for diseases. This approach considers the unique variations in an individual's genetic makeup, chromosomal abnormalities, and molecular profiles to diagnose, treat, and prevent illnesses. Precision Medicine encompasses various applications, including cancer, chronic diseases, CNS disorders, and rare genetic disorders. Environmental variability and behavioral variability also play a role in illness susceptibility and disease progression. The Precision Medicine Market presents significant opportunities for personalized therapeutics and diagnostics. Genetic testing, microarray/biochips, and genome sequencing are crucial technologies in this arena. Companion diagnostics, calculation methodology, computational techniques, and targeted gene therapy are also essential components. Reimbursement policies, regulations, and healthcare infrastructure significantly impact the Precision Medicine Market. Price tags, funding programs, public healthcare systems, and healthcare access are key considerations. The biopharmaceutical arena, including Orchard Therapeutics, is commercializing personalized treatment choices based on positive results from genetic testing and molecular profiles. Regulations, guidelines, and policies from regulatory bodies influence the development and commercialization of precision medicine therapeutics. Conventional treatment methods, genomic research, and genetic targeted therapies continue to evolve in this rapidly advancing field. The Precision Medicine Market offers opportunities for biopharmaceutical players in oncology applications and therapeutic approaches for various diseases. The root cause of diseases can be identified through precision medicine, enabling a more effective therapeutic approach. Personalized medicine, wider adoption, and opportunities for treating rare genetic disorders and other rare diseases are significant market drivers. Developing regions are also exploring the potential of precision medicine to improve healthcare outcomes. Table of Contents: 1 Executive Summary 2 Market Landscape 3 Market Sizing 4 Historic Market Size 5 Five Forces Analysis 6 Market Segmentation Application Oncology CNS Respiratory Immunology Others Technology Bioinformatics Gene Sequencing Drug Discovery Precision Molecular Diagnostic Big Data Analytics Geography North America Europe Asia Rest Of World (ROW) 7 Customer Landscape 8 Geographic Landscape 9 Drivers, Challenges, and Trends 10 Company Landscape 11 Company Analysis 12 Appendix About Technavio Technavio is a leading global technology research and advisory company. Their research and analysis focuses on emerging market trends and provides actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions. With over 500 specialized analysts, Technavio's report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavio's comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios. Contacts Technavio Research Jesse Maida Media & Marketing Executive US: +1 844 364 1100 UK: +44 203 893 3200 Email: [email protected] Website: www.technavio.com/ SOURCE TechnavioBreakthrough in scalable production of high-quality organoids

3 burning questions facing Iowa State football as offseason beginsPremier is prepared to override the courts by giving municipalities and police “enhanced legislative powers” to “dismantle” across Ontario. “We are acting to put an end to the public disorder, drug use and trafficking and loss of public space that have resulted from the widespread growth in encampments,” Ford said Thursday. His comments came in a response to to help them deal with encampments and “where necessary use the notwithstanding clause” to ensure any efforts aren’t overturned by the courts. “I am confident that the legislative authorities the province is preparing are common sense, practical and entirely aligned with the Charter of Rights and Freedoms, especially for the law-abiding residents who simply want to enjoy the benefits of their local public spaces,” the premier told them. “For that reason, I do not expect the legislation will need to proactively invoke Section 33 of the Charter of Rights and Freedoms,” he said. “However, should the courts interfere with our shared goal of effectively addressing and clearing out encampments using these enhanced tools, with your support, our government is fully prepared to use the notwithstanding clause.” His letter came after the mayors of Barrie, Brampton, Brantford, Cambridge, Chatham-Kent, Clarington, Oakville, Oshawa, Pickering, St. Catharines, Sudbury and Windsor appealed to him two weeks ago for help. They urged his government to “become an intervener on any court case that restricts the ability of municipalities to regulate and prohibit encampments” and “strengthen the existing system of mandatory community-based and residential mental health care and to expand service to treat those who have severe and debilitating addictions.” While there are more than 1,000 people living in tents in Toronto parks throughout the city, did not sign the letter. The premier agreed there is “an urgent need to do more and I am thrilled that you have shown considerable leadership in putting forward concrete and actionable solutions.” “Ontario is finalizing the details of new initiatives, including enhanced legislative powers, that will be responsive to your requests,” he wrote. “The new legislation and supporting initiatives will achieve the outcomes all of us agree are necessary in order to protect public safety and dismantle encampments.” Legislation, which is expected before the house rises for the holiday break next Thursday, will include a funding boost “to create more capacity in our shelter systems, supported by the new accountability measures to ensure these funds support dismantling encampments.” As well, it will gives police “new tools and authorities” to further curb the use of illicit drugs in public. Brampton Mayor Patrick Brown said he was “very pleased with the response from the premier.” “We don’t permit illicit drugs in our Peel shelters and it’s why we have seen encampments grow among those struggling with addictions,” said Brown. “We simply can’t have dangerous drug use in our parks and public spaces. The commitment to clearly prohibit it and back it up legally is helpful,” he said. “I just hope the next shoe to fall is compassionate intervention for addictions.” In Waterloo last year, a judge ruled that evicting those living in homeless encampments would be a violation of their Charter rights if no shelter spaces are available. A similar judicial ruling was also handed down in Kingston. Use of the notwithstanding clause which Ford has invoked before, being the first Ontario premier to use the Constitution’s nuclear option allows a government to pass legislation overriding certain rights. On Tuesday, the for his decision to close 10 of 17 Ontario’s supervised consumption sites in favour of 19 Homelessness and Addiction Recovery Treatment hubs. Auditor general Shelley Spence said shuttering the facilities near schools and daycares was made “without proper planning.”

Sony is reportedly in the early stages of developing a new PlayStation handheld device which would likely play PS4 and PS5 games natively. The report arrives courtesy of the ever-reliable , which posited a portable console, while years away, was being discussed privately, as a means to expand Sony’s reach into a new market. The PlayStation Portal, a cloud-based streaming handheld, is reportedly being used as a building block for Sony’s future plans. In fact, was told the device was originally meant to function as a standalone gaming handheld, much like the Steam Deck, before plans were changed. Sony is seemingly looking to revisit this intent in a new handheld device, with the aim for this to be “more accessible and appealing to a wider audience.” notes Sony has been aiming to expand PlayStation’s appeal for several years now, as it aims to make its games more widely accessible, beyond the PS5 ecosystem. Should Sony release a new PlayStation handheld device, it will likely be in contention with Microsoft – the company is – as well as Nintendo, which will announce a Nintendo Switch successor within the next six months, and Valve’s Steam Deck PC handheld. The handheld gaming market is heating up In the last few years, the race to create new gaming handhelds that allow a freedom for users has heated up significantly. What’s worth noting is Sony was formerly an expert in the gaming handheld market. The PlayStation Portable (PSP) was a very early experiment with the technology, and proved to be wildly popular in its era, thanks to robust developer support. It’s estimated the console sold around 80 million units in its ten-year life cycle, making it the 12th best-selling console of all time. Sadly, Sony’s followup device, the PlayStation Vita, fared much worse, selling an estimated 10-15 million units in its life cycle. While many factors influenced this lack of popularity, it’s commonly put down to a lack of developer support, with few major titles releasing on the console. Following this release, Sony largely abandoned its handheld gaming ambitions, instead focussing on launching home consoles for the next decade. Now, it appears the ambition and desire for dedicated handheld gaming devices may have returned – and Sony may once again dip its toes into the market. While believes a potential new PlayStation handheld device isn’t a sure thing, and Sony may choose to leave the idea behind should the market prove volatile, we’ll certainly be keeping an eye out for more updates.NEW YORK — The Giants may have to host the Saints on Sunday without their top offensive weapon, too. Rookie receiver Malik Nabers has a hip flexor, underwent an MRI on Friday morning and is in jeopardy of possibly missing the Week 14 home game, head coach Brian Daboll said. Nabers is officially listed as questionable and did not practice Friday at all. “They’re not ruling him out right now,” Daboll said. Nabers, 21, got hurt during the 1-on-1 portion of Thursday’s practice. He was listed as limited with a groin injury but then underwent further testing that revealed the new hip injury, according to the coach. Dexter Lawrence, the Giants’ top defensive player, is already out for the season with an elbow injury. Top left Andrew Thomas (foot) is done for the season. Top linebacker Bobby Okereke (back) is week-to-week. Daniel Jones is on the Vikings. And now Nabers may be joining the long list of Giants players unable to stay on the field during the stretch of this horrific season. “We wish we had Dexter and Andrew Thomas and those guys, but we don’t,” Daboll said. “That’s the reality of the NFL. So they’re looking forward to the opportunity, which will be a big challenge.” The Giants (2-10) have lost seven straight games and are 0-6 at MetLife Stadium. The Saints (4-8) already fired their coach Dennis Allen, and New Orleans is 0-3 in outdoor games, 1-4 on the road and 0-4 in their last four away games. But they’re still 4.5-point favorites. Interim Saints head coach Darren Rizzi, a native of Hillsdale, N.J., said this week that his team was flying to the area on Friday to do a walkthrough in the elements to prepare the players for the cold weather. New Orleans lost dual threat quarterback/tight end Taysom Hill (knee) for the season last Sunday, but otherwise, they’re down backup guard Nick Saldiveri (knee) and wideout Bub Means (ankle). And defensive lineman Tanoh Kpassagnon (Achilles) and running back Kendre Miller (hamstring) are questionable. The Giants’ injury report is comparably bleak. Top corner Deonte Banks (rib), Lawrence and defensive tackle Rakeem Nuñez-Roches (neck/shoulder) and Okereke (back) are all out. Defensive tackle D.J. Davidson (shoulder) and offensive tackle Jermaine Eluemunor (quad) are doubtful. And six players are questionable: Nabers, offensive tackles Evan Neal (hip) and Chris Hubbard (knee), defensive tackle Jordon Riley (knee), corner Dru Phillips (shoulder) and linebacker Dyontae Johnson (ankle). Hubbard and Phillips did not practice Friday, either. ©2024 New York Daily News. Visit nydailynews.com . Distributed by Tribune Content Agency, LLC.

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Chris Pratt and Katherine Schwarzenegger ’s baby boy is getting his moment in the spotlight. The Good Night, Sister author showed off her jam-packed November, which included the arrival of her and Chris’ third child together , Ford Fitzgerald Schwarzenegger Pratt , and gave the world the first glimpse of her baby boy. In the Dec. 6 post, which she simply captioned, “November,” Katherine, who also shares daughters Lyla , 4, and Eloise , 2, with Chris, lead with a photo of little Ford’s feet covered in plush socks that are the perfect match to his cozy onesie. The infant made another appearance, as the 34-year-old shared a picture of her cradling her baby bump in a pink dress, and a shot of a Ford onesie. And she even shared how her family was getting into the holiday spirit, with snaps of Lyla and Eloise in matching Grinch pajamas and a cute shot showing off their little red nails. Katherine and Chris—who is also dad to son Jack , 12, with ex-wife Anna Faris —announced their baby boy’s arrival last month, just four months after confirming her pregnancy . "We are overjoyed to announce the birth of our son," they shared on Instagram Nov. 11. "Mama and baby are doing well and Ford’s siblings are thrilled by his arrival. We feel so blessed and grateful. Love, Katherine and Chris." A post shared by Katherine Schwarzenegger (@katherineschwarzenegger) The Guardians of the Galaxy star didn’t hesitate to gush about his children. "They are cute and they're wonderful," Chris told E! News in May. "They're sweet, polite, kind, joyous little angels, and I love them." He also didn’t hold back as she shared his and Katherine’s approach to parenting and the way they are fostering healthy emotions in their children. "I think there's a new age of parenting," he continued. "I grew up, I did exactly what my parents said all the time. I never knew I could say 'no' to my parents. And now I'm a guy who didn't have a super healthy grip on his own emotions. So we're trying to raise them in a way that they feel comfortable expressing themselves." Keep reading for more of Katherine and Chris’ cutest moments... In June 2018, an insider told E! News that Chris Pratt was "smitten" with Katherine Schwarzenegger , adding that the Jurassic World star was "super happy" about the start of their blossoming relationship . Meeting the Family The couple took their romance to next level by spending time with the Schwarzenegger family . As it turned out, Katherine's mom Maria Shriver played matchmaker after meeting Chris through church. Getting Close With the Pratts By September 2018, Katherine was hanging out with the Jurassic World star's family and friends. The couple were all smiles during their outing Chris' brother Cully Pratt . Birthday Tribute "Happy Birthday Chief!" Chris captioned a series of never-before-seen snapshots in December 2018. "Your smile lights up the room. I've cherished our time together. Thrilled God put you in my life. Thankful for the laughs, kisses, talks, hikes, love and care." Chris popped the question to Katherine in Montecito, Calif., with the duo announcing their engagement in January 2019. "Sweet Katherine, so happy you said yes!" Chris wrote on Instagram. "I'm thrilled to be marrying you. Proud to live boldly in faith with you. Here we go!" Red Carpet Date The two make their red carpet debut as a couple at the Avengers: Endgame premiere in Los Angeles in April 2019. California Wedding Katherine and Chris wed in June 2019 at a star-studded ceremony on San Ysidro Ranch in Montecito, Calif. Celebrity guests included Katherine's dad Arnold Schwarzenegger , G uardians of the Galaxy director James Gunn and Chris' Parks and Recreation costar Rob Lowe . The pair spent the pandemic together, with the Marvel star adorably crashing the author one of the author's baking videos. Oh Baby! In April 2020, E! News learned that Katherine was pregnant with the couple's first child together . Little Lyla "We are beyond thrilled to announce the birth of our daughter , Lyla Maria Schwarzenegger Pratt ," the couple shared in an August 2020 Instagram post. "We couldn't be happier. Both mom and baby are doing great. We are extremely blessed." Katherine shared this photo of her husband in June 2021. Double the Joy In December 2021, news broke that Chris and Katherine were expecting their second baby together . Hello Eloise The duo welcomed daughter Eloise Christina Schwarzenegger Pratt on May 21, 2022. "We are so excited to announce the birth of our second daughter," they shared in a Instagram statement a day later. "Mama and baby are doing well. We feel beyond blessed and grateful. Love, Katherine and Chris." Daddy Dearest Katherine posted this pic of her husband with their youngest daughter on Father's Day 2022. Baby No. 3 They became parents again in November 2024 with the arrival of son Ford Fitzgerald Schwarzenegger Pratt .

Pride, bragging rights and more than $115M at stake when final college playoff rankings come out“Cassoulet, that best of bean feasts, is everyday fare for a peasant but ambrosia for a gastronome.” ~ Julia Child When winter heads our way, bringing chilly temperatures and close, dark nights, my thoughts turn to Cassoulet, the iconic comfort food from southwestern France. It has it all – juicy beans, duck leg confit, sausages and sometimes pork or lamb, slowly simmered in well-seasoned broth, then baked in a wide-mouthed, glazed terra-cotta dish called a cassole . Like any truly traditional dish, there are multiple versions, all claiming to be the “authentic one.” Cassoulet originated in southwestern France. Toulouse claims it — and so does Castelnaudary and Carcassonne — and the recipes vary. Toulouse adherents eschew adding cubed pork. Castelnaudary purists add a bit of lamb, while Carcassonne’s adds partridge. In most restaurants, cassoulets are served in an individual cassole , bubbling with hot juices,and with a bit of duck leg peeking through the top. But at Hostellerie Etienne , a vast indoor- outdoor restaurant on the edge of a forest near Castelnaudary, the cassoulets come to the table in family-size cassoles , big enough to serve two, four, six or even 10 people, so you can share the dish with your dining companions. I don’t know if Etienne’s even has a single-serving bowl size. I didn’t see one, when I was there as the guest of a bean trader from Castelnaudary. According to him, Etiennne’s has the best cassoulet anywhere, and they use the Lauragais lingot beans known as the Castelnaudary bean. Copious doesn’t begin to describe the cassoulet scene there, with stacks of cassoles lined up in Etienne’s kitchen, next to caldrons of simmering beans, ready to be filled and popped into the vast ovens. Here in the Bay Area, we have our own go-to restaurants for cassoulets. Some, like the Left Bank Brasseries in San Jose, Menlo Park, Oakland and Larkspur, and Reve Bistro in Lafayette, only serve it during the winter months as a special. (Reve will be serving cassoulet Dec. 10-14, for example, and Jan. 7-11; reserve it when you reserve your table.) Others, such as Bistro Jeanty in Yountville and Le Central in San Francisco, always have it on the menu. Both Reve Bistro and Bistro Jeanty use cassoles made by potter Kathy Kernes at her Crockett Pottery in Crockett, and they are every bit as beautiful and as practical as those you’ll find in southwestern France. Kernes’ makes cassoles in six sizes ($38-$210), ranging from individual to “extra large plus,” which is very large indeed. (Browse the possibilities at www.crockettpottery.com.) Reve Bistro offers take-out cassoulets if you pre-order the week the dish is on the menu. Pick it up — in a takeout container, not a cassole! — then heat it at home. Just note that chef-owner Paul Magu-Lecugy only makes a limited number of portions. “It’s time consuming,” he says, noting for him, it is a two-day process. Le Central’s cassoulet is one of the more elaborate around, with lamb, pork shoulder and boudin blanc, as well as the all-important duck leg confit and slightly garlicky Toulouse sausage. Left Bank uses chef-owner Roland Passot’s recipe (see below) and keeps it simple, limiting the meats to duck leg confit and Toulouse sausages. (Don’t panic. If you’re making this at home, some specialty markets sell duck confit.) The beans are key to cassoulet. Once cooked, they should not be mushy, but hold their shape after the long cooking. In France, tradition calls for either Tarbais beans, a plump, white bean, or lingot beans — a strain of cannellini beans — in making cassoulet. As Passot suggests in his recipe below, you can substitute cannellini beans or Great Northern beans. Rancho Gordo produces a variety called cassoulet , a West Coast-grown bean from the Tarbais strain. Cassoulet isn’t difficult to make. It just requires time and patience. You can make it a couple of days ahead, refrigerate it and then slowly reheat it. That way, there’s nothing to do on the day of but sip a glass of wine while the beans and meats slowly heat to bubbling. Add a green salad and some crusty bread, and you’ll have the perfect winter meal. Or put your coat on and head to one of our local restaurants, where the cooking is done for you. All you need is a reservation. Serves 6 to 8 Beans: 4 cups dried lingot beans (white kidney, cannellini or Great Northern, will all work) 1 small carrot, peeled and chopped 1 small onion, diced (about 3⁄4 cup) 1 clove garlic, chopped 1 pound slab bacon or extra thick-cut bacon, cut into 1-inch cubes 2 sprigs of thyme 1 bay leaf Cassoulet: 1⁄4 cup duck fat (lard will do in a pinch) 2 pounds pork butt cut in 2-inch cubes 1 cup onions, diced small 4 cloves garlic, chopped 1⁄4 cup tomato paste 1 small can diced tomatoes 11⁄2-2 cups reserved bean water 6 Toulouse sausages 1 small garlic sausage 4 confit duck legs, purchased or homemade (see note below) 1 cup panko bread crumbs 1 teaspoon garlic, chopped 1 tablespoon parsley, chopped 1⁄4 teaspoon fresh thyme, chopped 1 tablespoon extra virgin olive oil Note: If you are making your own duck confit, start the night before by rubbing the duck legs with a “green salt” mixture — kosher salt, parsley, a couple of bay leaves and thyme ground together. The next day, rinse the duck legs well, pat dry and place in an oven-safe cooking vessel with enough duck fat to cover the legs. Roast in a 225-degree oven for 21⁄2 to 3 hrs. The night before, place the beans in a deep pot and add enough water to cover by 2 inches. Let beans soak overnight. The next day, rinse the beans well. Add the rinsed beans, carrots, onions, garlic, bacon, thyme and bay leaf to cold water and cook, over low heat, until the beans are tender. Strain the beans, saving the water, and set aside the beans. In a large braising pan, melt the duck fat over medium high heat. Once the pan is hot, brown the pork butt pieces without stirring. When beginning to brown, start stirring, making sure you scrape the bottom if it starts to caramelize. The pork doesn’t need much color, but it does need to cook in the duck fat for a while. Add lots of salt and pepper. This is not a shy dish. When the pork is nice and brown on all sides, add the 1 cup onions and garlic, and sauté until the onions are soft and cooked through. Add the tomato paste, diced tomatoes and reserved liquid from the beans. Stir, using a rubber spatula to clean the side of the pot. Preheat your oven to 250 degrees. Bring the heat under the braising pan up to high. Once at a rolling boil, turn down to low heat and add all the sausages. When they are cooked through, remove and set aside. Slice the garlic sausage in half and cut into 1-inch pieces. Return the whole and sliced sausages back to the pot along with the cooked beans. Continue to cook on low heat until the pork is cooked through. Taste for seasoning; add more salt and pepper if needed. Transfer the beans and pork to a heavy, wide mouth, earthenware, clay or cast iron baking dish that can hold 5 to 6 quarts. Bake at 250 degrees for about 11⁄2 hours, checking at least every 30 minutes. It may require a bit more time. If the dish is starting to look too dry, add a small amount of reserved bean broth or chicken stock. Add warmed duck legs to the cassoulet and make a breadcrumb topping by combining the panko, garlic, parsley, thyme and extra virgin olive oil. Return the dish to the oven and continue baking until the crumbs brown on the top. — Courtesy Roland Passot, Propriétaire, Chef Culinary Officer, Vine HospitalityLions host Packers on Thursday night, hoping to push winning streak to franchise-record 11 straight

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CAPE CANAVERAL, Fla. (AP) — Known across the globe as the stuck astronauts, Butch Wilmore and Suni Williams hit the six-month mark in space Thursday with two more to go. The pair rocketed into orbit on June 5, the first to ride Boeing’s new Starliner crew capsule on what was supposed to be a weeklong test flight. They arrived at the International Space Station the next day, only after overcoming a cascade of thruster failures and helium leaks . NASA deemed the capsule too risky for a return flight, so it will be February before their long and trying mission comes to a close. While NASA managers bristle at calling them stuck or stranded, the two retired Navy captains shrug off the description of their plight. They insist they’re fine and accepting of their fate. Wilmore views it as a detour of sorts: “We’re just on a different path.” “I like everything about being up here,” Williams told students Wednesday from an elementary school named for her in Needham, Massachusetts, her hometown. "Just living in space is super fun.” Both astronauts have lived up there before so they quickly became full-fledged members of the crew, helping with science experiments and chores like fixing a broken toilet, vacuuming the air vents and watering the plants. Williams took over as station commander in September. “Mindset does go a long way,” Wilmore said in response to a question from Nashville first-graders in October. He’s from Mount Juliet, Tennessee. “I don’t look at these situations in life as being downers.” Boeing flew its Starliner capsule home empty in September, and NASA moved Wilmore and Williams to a SpaceX flight not due back until late February. Two other astronauts were bumped to make room and to keep to a six-month schedule for crew rotations. Like other station crews, Wilmore and Williams trained for spacewalks and any unexpected situations that might arise. “When the crews go up, they know they could be there for up to a year,” said NASA Associate Administrator Jim Free. NASA astronaut Frank Rubio found that out the hard way when the Russian Space Agency had to rush up a replacement capsule for him and two cosmonauts in 2023, pushing their six-month mission to just past a year. Boeing said this week that input from Wilmore and Williams has been “invaluable" in the ongoing inquiry of what went wrong. The company said in a statement that it is preparing for Starliner's next flight but declined comment on when it might launch again. NASA also has high praise for the pair. “Whether it was luck or whether it was selection, they were great folks to have for this mission,” NASA's chief health and medical officer, Dr. JD Polk, said during an interview with The Associated Press. On top of everything else, Williams, 59, has had to deal with “rumors,” as she calls them, of serious weight loss. She insists her weight is the same as it was on launch day, which Polk confirms. During Wednesday's student chat, Williams said she didn't have much of an appetite when she first arrived in space. But now she's “super hungry” and eating three meals a day plus snacks, while logging the required two hours of daily exercise. Williams, a distance runner, uses the space station treadmill to support races in her home state. She competed in Cape Cod’s 7-mile Falmouth Road Race in August. She ran the 2007 Boston Marathon up there as well. She has a New England Patriots shirt with her for game days, as well as a Red Sox spring training shirt. “Hopefully I’ll be home before that happens -- but you never know,” she said in November. Husband Michael Williams, a retired federal marshal and former Navy aviator, is caring for their dogs back home in Houston. As for Wilmore, 61, he's missing his younger daughter's senior year in high school and his older daughter's theater productions in college. “We can’t deny that being unexpectedly separated, especially during the holidays when the entire family gets together, brings increased yearnings to share the time and events together,” his wife, Deanna Wilmore, told the AP in a text this week. Her husband “has it worse than us” since he's confined to the space station and can only connect via video for short periods. “We are certainly looking forward to February!!” she wrote. The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

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